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Πειραματική θεραπεία κατά της μετάστασης καρκίνου μαστού και ωοθηκών

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ΚΑΡΚΙΝΟΣ, ΜΕΤΑΣΤΑΣΗ ΚΑΡΚΙΝΟΥ, ΚΑΡΚΙΝΟΣ ΜΑΣΤΟΥ, ΚΑΡΚΙΝΟΣ ΩΟΘΗΚΩΝ

Μία νέα μη τοξική πειραματική θεραπεία η οποία βασίζεται στη δημιουργία της πρωτεΐνης Axl, μέσω της βιοτεχνολογίας,  και έχει ως στόχο να αποτρέψει τη δημιουργία μετάστασης στις περιπτώσεις του καρκίνου του μαστού και των ωοθηκών, ανέπτυξαν ερευνητές της Σχολής Μηχανικής του Πανεπιστημίου Στάνφορντ.


Οι ερευνητές της Καλιφόρνια, με επικεφαλής την αναπληρώτρια καθηγήτρια εμβιομηχανικής Τζένιφερ Κόχραν, έκαναν τη σχετική δημοσίευση στο περιοδικό βιοχημείας "Nature Chemical Biology. Σύμφωνα με τα στοιχεία, χορήγησαν ενδοφλέβια την σκοπίμως τροποποιημένη πρωτεΐνη Axl σε ποντίκια με προχωρημένο καρκίνο του μαστού ή των ωοθηκών. Μετά την θεραπεία, τα ποντίκια με καρκίνο του μαστού είχαν 78% λιγότερες μεταστάσεις, ενώ αυτά με καρκίνο των ωοθηκών εμφάνιζαν ακόμη πιο θεαματική μείωση 90% στις μεταστάσεις τους, σε σχέση με τα ποντίκια (ομάδα ελέγχου) που δεν είχαν πάρει την ίδια θεραπεία, ώστε να γίνει σύγκριση.


«Είναι μια πολλά υποσχόμενη θεραπεία που φαίνεται να είναι αποτελεσματική και μη τοξική, σύμφωνα με τα προκλινικά πειράματα. Μπορεί να εγκαινιάσει μια νέα προσέγγιση στην αντικαρκινική θεραπεία», δήλωσε ο καθηγητής Αμάτο Τζιακία, επικεφαλής του Προγράμματος Βιολογίας των Ακτινοβολιών στο Κέντρο Καρκίνου του Στάνφορντ.


Σημαντικό ρόλο στη νέα θεραπεία έχει παίξει ο ελληνικής καταγωγής Μιχάλης Καριόλης, ο οποίος έχει ειδικευτεί στην «κατευθυνόμενη εξέλιξη», δηλαδή στη γενετική «χειραγώγηση» και o οποίος ήταν ο κύριος συγγραφέας της νέας δημοσίευσης.